TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.74.1.1









Integrin β-like protein A of 1927 aas and 2 TMSs, N- and C-terminal, Sib1 of the TM9 (Phg1) family. Serves as an intramembrane cargo receptor controlling exocytosis and surface localization of a subset of membrane proteins (Perrin et al. 2015).

Eukaryota
Dictyosteliida
Sib1 of Dictyostelium discoideum (Slime mold)
*8.A.74.1.2









Neurexin-1 (NRX1) of 1477 aas and 2 TMSs, one N-terminal and one C-terminal.  It is a cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission including several transport systems. Neurexin function is isoform-specific. It is found in trans-synaptic tripartite complexes which consist of one unit of the cerebellin-1 (Cbln1) hexamer,  four monomeric neurexins containing a splice site 4 insertion at presynaptic terminals and the postsynaptic GluD2 dimers (Matsuda 2016). The trans-synaptic interaction of postsynaptic glutamate receptor δ2 (GluRδ2, an orthologue of TC#1.A.10.1.8) and presynaptic neurexins through cerebellin precursor protein 1 (Cbln1) mediates synapse formation in vivo in the cerebellum (Lee et al. 2012). Members of the neurexin family appear to be homologous to domains in some members of TC family 9.B.87.

Eukaryota
Metazoa
Neurexin-1 of Homo sapiens