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8.A.77 The Sheddase (Sheddase) Family 

Ectodomain shedding of integral membrane receptors, channels and transporters results in the release of soluble molecules and modification of the transmembrane portions of the substrate proteins to mediate or modulate extracellular and intracellular signalling. Ectodomain shedding is stimulated by a variety of mechanisms, including the activation of P2 receptors by extracellular nucleotides.  Metalloproteinases play the primary role in the shedding of various cell surface molecules including amyloid precursor protein, CD23, CD62L, and members of the epidermal growth factor, immunoglobulin and tumour necrosis factor families. Pupovac and Sluyter 2016 discuss the mechanisms involved in shedding, demonstrating central roles for the P2 receptors, P2X7 (TC# 1.A.7.1.3) and P2Y2 (TC# 9.A.14.13.16), and the sheddases, ADAM10 and ADAM17, in this process.

ADAM10) is ubiquitously expressed, essential for embryonic development through activation of Notch proteins. ADAM10 regulates over 40 other transmembrane proteins and acts as a 'molecular scissor' by removing their extracellular regions. It is also a receptor for alpha-toxin, a major virulence factor of Staphylococcus aureus.

The ADAM11 protein (8.A.77.2.1) is an auxilary protein responsible for the localization of Kv1.1 and Kv1.2 K+ channel subunit complexes to the distal terminai of certain nerve cells (Kole et al. 2015).  Direct interaction with Kv1 channel proteins has been demonstrated.

References associated with 8.A.77 family:

Guo, S., M. Peng, Q. Zhao, and W. Zhang. (2012). Role of ADAM10 and ADAM17 in CD16b shedding mediated by different stimulators. Chin Med Sci J 27: 73-79. 22770404
Jowett, J.B., Y. Okada, P.J. Leedman, J.E. Curran, M.P. Johnson, E.K. Moses, H.H. Goring, S. Mochizuki, J. Blangero, L. Stone, H. Allen, C. Mitchell, and V.B. Matthews. (2012). ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-α. Immunol Cell Biol 90: 966-973. 23010875
Kole, M.J., J. Qian, M.P. Waase, T.L. Klassen, T.T. Chen, G.J. Augustine, and J.L. Noebels. (2015). Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J. Neurosci. 35: 11433-11444. 26269648
Malinin, N.L., S. Wright, P. Seubert, D. Schenk, and I. Griswold-Prenner. (2005). Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity. Proc. Natl. Acad. Sci. USA 102: 3058-3063. 15710903
Mathews, J.A., D.R. Gibb, B.H. Chen, P. Scherle, and D.H. Conrad. (2010). CD23 Sheddase A disintegrin and metalloproteinase 10 (ADAM10) is also required for CD23 sorting into B cell-derived exosomes. J. Biol. Chem. 285: 37531-37541. 20876574
Prox, J., M. Willenbrock, S. Weber, T. Lehmann, D. Schmidt-Arras, R. Schwanbeck, P. Saftig, and M. Schwake. (2012). Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10. Cell Mol Life Sci 69: 2919-2932. 22446748
Pupovac, A. and R. Sluyter. (2016). Roles of extracellular nucleotides and P2 receptors in ectodomain shedding. Cell Mol Life Sci. [Epub: Ahead of Print] 27180276
Vázquez, F., G. Hastings, M.A. Ortega, T.F. Lane, S. Oikemus, M. Lombardo, and M.L. Iruela-Arispe. (1999). METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J. Biol. Chem. 274: 23349-23357. 10438512
Virreira Winter, S., A. Zychlinsky, and B.W. Bardoel. (2016). Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity. Sci Rep 6: 24242. 27066838
von Hoven, G., A.J. Rivas, C. Neukirch, S. Klein, C. Hamm, Q. Qin, M. Meyenburg, S. Füser, P. Saftig, N. Hellmann, R. Postina, and M. Husmann. (2016). Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus α-toxin action. Biochem. J. 473: 1929-1940. 27147619
Wewer, U.M., M. Mörgelin, P. Holck, J. Jacobsen, M.C. Lydolph, A.H. Johnsen, M. Kveiborg, and R. Albrechtsen. (2006). ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme. J. Biol. Chem. 281: 9418-9422. 16455653