TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.83.1.1









Shisa6 of 500 aas and 2 TMSs, one N-terminal and one at position 176 - 195.  Interacts with AMPA receptors (TC# 1.A.10) at post synaptic sites and prevents desensitization (Klaassen et al. 2016).

Eukaryota
Metazoa
Shisa6 of Homo sapiens
*8.A.83.1.2









Shisa8 protein of 492 aas and 2 TMSs with a Class II PDZ domain. Regulates short term neuronal synaptic plasticity.  Present in the olfactory bulb and cerebellum.  Involved in prolongation of deactivation and an increase in desensitization of GluA2 without change in that of GluA1. It slowed recovery from desensitization, enhanced of glutamate potency, and reducted cyclothiazide potency (Kato and Witkin 2018).

Eukaryota
Metazoa
Shisa8 of Homo sapiens
*8.A.83.1.3









Shisa9, or CKAMP44 of 424 aas and 2 TMSs. Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. It associates with AMPA receptors (ionotropic glutamate receptors; TC#1/A/10) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses. It is found in the dentate gyrus and olfactory bulb. It has a class II PDZ domain and is expressed in a majority of regions of the brain.  It slows recovery from desensitization, enhances glutamate potency and reduces cyclothiazide potency and efficacy (Kato and Witkin 2018).

Eukaryota
Metazoa
Shisa9 of Homo sapiens
*8.A.83.1.4









Shisa7 of 538 aas and 2 TMSs.  It is a AMPAR modulatory protein affecting channel kinetics of AMPARs, necessary for synaptic hippocampal plasticity and memory recall (Schmitz et al. 2017).

Bacteria
Proteobacteria
Shisa7 of Homo sapiens