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8.A.83.1.2
Shisa8 protein of 492 aas and 2 TMSs with a Class II PDZ domain. Regulates short term neuronal synaptic plasticity.  Present in the olfactory bulb and cerebellum.  Involved in prolongation of deactivation and an increase in desensitization of GluA2 without change in that of GluA1. It slowed recovery from desensitization, enhanced of glutamate potency, and reducted cyclothiazide potency (Kato and Witkin 2018).

Accession Number:B8ZZ34
Protein Name:Putative protein shisa-8
Length:492
Molecular Weight:51412.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate

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FASTA formatted sequence
1:	MARAGARGLL GGRRPPGLRL ALALRLALLL ARPPSGRAGA PEAQGPAAPG TTAPEGGDRC 
61:	RGYYDVMGQW DPPFNCSSGA YSFCCGTCGY RFCCHDGPRR LDQSRCSNYD TPAWVQTGRP 
121:	PARARDTAAP RDPGRERSHT AVYAVCGVAA LLVLAGIGAR LGLERAHSPR ARRTVTRALT 
181:	ELLKQPGPQE PLPPTLGPPL GGCVQVQMGD GLPRGSPHNS AGPRTPRLAR ASPPGEPFMR 
241:	VAPPGLAAAA AARDSEPGPV PGAGGCGEDR LGSQPRPENG PPGSHRTASG RGLRRGDSEG 
301:	GVNRGIGPSR VSLLAPDKKR LNNAPRGSAA PGPPRGPRLQ GGGSLTLQPD YAKYATFKAA 
361:	ALKAAEAAPR DFCQRFPALE PSPRQPPARA PRPSPDLPAP LDACPWAPPV YAPPAAPGPY 
421:	AAWTSSRPAR PAPLSHPTAR AFQVPRRPGH AARRQFSVKM PETFNPQLPG LYGSAGRGSR 
481:	YLRTNSKTEV TV