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8.A.83.1.3
Shisa9, or CKAMP44 of 424 aas and 2 TMSs. Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. It associates with AMPA receptors (ionotropic glutamate receptors; TC#1/A/10) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses. It is found in the dentate gyrus and olfactory bulb. It has a class II PDZ domain and is expressed in a majority of regions of the brain.  It slows recovery from desensitization, enhances glutamate potency and reduces cyclothiazide potency and efficacy (Kato and Witkin 2018).

Accession Number:B4DS77
Protein Name:Protein shisa-9
Length:424
Molecular Weight:46925.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell projection1 / Single-pass type I membrane protein2
Substrate

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FASTA formatted sequence
1:	MRRVLRLLLG CFLTELCARV CRAQERAGHG QLAQLGGVLL LAGGNRSGAA SGEASEGAEA 
61:	SDAPPTRAPT PDFCRGYFDV MGQWDPPFNC SSGDFIFCCG TCGFRFCCTF KKRRLNQSTC 
121:	TNYDTPLWLN TGKPPARKDD PLHDPTKDKT NLIVYIICGV VAVMVLVGIF TKLGLEKAHR 
181:	PQREHMSRAL ADVMRPQGHC NTDHMERDLN IVVHVQHYEN MDTRTPINNL HATQMNNAVP 
241:	TSPLLQQMGH PHSYPNLGQI SNPYEQQPPG KELNKYASLK AVGSSDGDWA VSTLKSPKAD 
301:	KVNDDFYTKR RHLAELAAKG NLPLHPVRVE DEPRAFSPEH GPAKQNGQKS RTNKMPPHPL 
361:	AYTSTTNFKG WDPNEQSLRR QAYSNKGKLG TAETGSSDPL GTRPQHYPPP QPYFITNSKT 
421:	EVTV