TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.87.1.1









AS160, TBC1 domain family member 4 of 1298 aas and 3 or 4 TMSs, one N-terminal and 3 C-terminal.  It regulates energy utilization and promotes translocation of various transporters from an intracellular site to the plasma membrane.  These include the glucose transporter, GLUT4, and several proteins involved in fatty acid transport (Mikłosz et al. 2016).

Eukaryota
Metazoa
AS160 of Homo sapiens
*8.A.87.1.2









Tbc domain protein of 745 aas and 2 or 3 TMSs

Eukaryota
Fungi
Tcb domain protein of Sporothrix insectorum
*8.A.87.1.3









TBC1 homologue of 1159 aas and 3 or 4 TMSs. 

Eukaryota
Metazoa
TBC1 homologue of Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
*8.A.87.1.4









TBC1D1 of 1168 aas and 3 or 4 TMSs as for TBC1D4 which is 50 % identical to TBC1D1 (Cartee 2015).

Eukaryota
Metazoa
TBC1D1 of Homo sapiens
*8.A.87.1.5









Small G-protein signaling modulator, Sgsm3, (Cip85, Rutbc3) of 749 aas.  Interacts with connexin 43 and probably regulates gap junctional permeability (Giepmans 2006).

Eukaryota
Metazoa
Cip85 of Homo sapiens
*8.A.87.1.6









NOV (CCN3, NOVH, IGFBP9) of 357 aas and 3 putative TMSs.  Binds and may regulate Connexin 43, influencing gap junctional permeability (Giepmans 2006).

Eukaryota
Metazoa
NOV of Homo sapiens
*8.A.87.2.1









TBC1 domain family member 5 of 795 aas and 2 or 3 putative TMSs.  It may act as a GTPase-activating protein (GAP) for Rab family proteins and can displace RAB7A and the retromer CSC subcomplex from the endosomal membrane to the cytosol (Seaman et al. 2009; Harbour et al. 2010).  Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network and for regulation of autophagy (Popovic et al. 2012). It may act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction (Popovic and Dikic 2014). Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling (Kvainickas et al. 2019).

 

Eukaryota
Metazoa
TBC1D5 of Homo sapiens