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8.A.9.1.2
Neutral and basic amino acid transport protein rBAT (NBAT) (B(0,+)-type amino acid transport protein) (D2h)

Accession Number:Q07837
Protein Name:Neutral and basic amino acid transport protein rBAT
Length:685
Molecular Weight:78852.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type II membrane protein2
Substrate NONE

Cross database links:

Genevestigator: Q07837
eggNOG: COG0366
HEGENOM: HOG000220640
Entrez Gene ID: 6519   
Pfam: PF00128   
Drugbank: Drugbank Link   
KEGG: hsa:6519   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0005743 C:mitochondrial inner membrane
GO:0005774 C:vacuolar membrane
GO:0015174 F:basic amino acid transmembrane transporter activity
GO:0003824 F:catalytic activity
GO:0043169 F:cation binding
GO:0015184 F:L-cystine transmembrane transporter activity
GO:0005975 P:carbohydrate metabolic process
GO:0006520 P:cellular amino acid metabolic process
GO:0006811 P:ion transport

References (18)

[1] “Cloning and chromosomal localization of a human kidney cDNA involved in cystine, dibasic, and neutral amino acid transport.”  Lee W.-S.et.al.   8486766
[2] “Expression cloning of a human renal cDNA that induces high affinity transport of L-cystine shared with dibasic amino acids in Xenopus oocytes.”  Bertran J.et.al.   7686906
[3] “Effects of truncation of the COOH-terminal region of a Na+-independent neutral and basic amino acid transporter on amino acid transport in Xenopus oocytes.”  Miyamoto K.et.al.   8663184
[4] “Genomic organization of a human cystine transporter gene (SLC3A1) and identification of novel mutations causing cystinuria.”  Endsley J.K.et.al.   9186880
[5] “Human cystinuria-related transporter: localization and functional characterization.”  Mizoguchi K.et.al.   11318953
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Luminal heterodimeric amino acid transporter defective in cystinuria.”  Pfeiffer R.et.al.   10588648
[10] “Genetic heterogeneity in cystinuria: the SLC3A1 gene is linked to type I but not to type III cystinuria.”  Calonge M.J.et.al.   7568194
[11] “Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome.”  Jaeken J.et.al.   16385448
[12] “Cystinuria caused by mutations in rBAT, a gene involved in the transport of cystine.”  Calonge M.J.et.al.   8054986
[13] “Mutations in the SLC3A1 transporter gene in cystinuria.”  Pras E.et.al.   7539209
[14] “Molecular genetics of cystinuria: identification of four new mutations and seven polymorphisms, and evidence for genetic heterogeneity.”  Gasparini P.et.al.   7573036
[15] “Mutations of the basic amino acid transporter gene associated with cystinuria.”  Miyamoto K.et.al.   7575432
[16] “Identification of two novel mutations [P122S (364C>T) and 1601delAC] in the SLC3A1 gene in type I cystinurics.”  Gitomer W.L.et.al.   10738006
[17] “Identification of 12 novel mutations in the SLC3A1 gene in Swedish cystinuria patients.”  Harnevik L.et.al.   11748844
[18] “Cystinuria in children: distribution and frequencies of mutations in the SLC3A1 and SLC7A9 genes.”  Botzenhart E.et.al.   12234283

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEDKSKRDS IEMSMKGCQT NNGFVHNEDI LEQTPDPGSS TDNLKHSTRG ILGSQEPDFK 
61:	GVQPYAGMPK EVLFQFSGQA RYRIPREILF WLTVASVLVL IAATIAIIAL SPKCLDWWQE 
121:	GPMYQIYPRS FKDSNKDGNG DLKGIQDKLD YITALNIKTV WITSFYKSSL KDFRYGVEDF 
181:	REVDPIFGTM EDFENLVAAI HDKGLKLIID FIPNHTSDKH IWFQLSRTRT GKYTDYYIWH 
241:	DCTHENGKTI PPNNWLSVYG NSSWHFDEVR NQCYFHQFMK EQPDLNFRNP DVQEEIKEIL 
301:	RFWLTKGVDG FSLDAVKFLL EAKHLRDEIQ VNKTQIPDTV TQYSELYHDF TTTQVGMHDI 
361:	VRSFRQTMDQ YSTEPGRYRF MGTEAYAESI DRTVMYYGLP FIQEADFPFN NYLSMLDTVS 
421:	GNSVYEVITS WMENMPEGKW PNWMIGGPDS SRLTSRLGNQ YVNVMNMLLF TLPGTPITYY 
481:	GEEIGMGNIV AANLNESYDI NTLRSKSPMQ WDNSSNAGFS EASNTWLPTN SDYHTVNVDV 
541:	QKTQPRSALK LYQDLSLLHA NELLLNRGWF CHLRNDSHYV VYTRELDGID RIFIVVLNFG 
601:	ESTLLNLHNM ISGLPAKMRI RLSTNSADKG SKVDTSGIFL DKGEGLIFEH NTKNLLHRQT 
661:	AFRDRCFVSN RACYSSVLNI LYTSC