TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.A.9.2.1
4F2hc of 527 aas and 1 TMS.  The 4F2/CDC98 cell surface receptor is involved in internalization of beta-defensin 3 (Colavita et al. 2015).

Accession Number:Q64304
Protein Name:4F2hc aka LLAT
Length:527
Molecular Weight:58072.00
Species:Rattus leucopus (mottle-tailed rat), and OS Rattus norvegicus (Rat) [10115]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate NONE

Cross database links:

Pfam: PF00128   

Gene Ontology

GO:0003824 F:catalytic activity
GO:0043169 F:cation binding
GO:0015175 F:neutral amino acid transmembrane transporte...
GO:0005975 P:carbohydrate metabolic process
GO:0060356 P:leucine import

References (1)

[1] “The 4F2hc surface antigen is necessary for expression of system L-like neutral amino acid-transport activity in C6-BU-1 rat glioma cells: evidence from expression studies in Xenopus laevis oocytes.”  Broer S.et.al.   8554532

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSQDTEVDMK DVELNELEPE KQPMNAADGA AAGEKNGLVK IKVAEDEAEA GVKFTGLSKE 
61:	ELLKVAGSPG WVRTRWALLL LFWLGWLGML AGAVVIIVRA PRCRELPVQR WWHKGALYRI 
121:	GDLQAFVGPE ARGIAGLKNH LEYLSTLKVK GLVLGPIHKN QKDEVNETDL KQIDPDLGSQ 
181:	EDFKDLLQSA KKKSIHIILD LTPNYKGQNA WFLPPQADIV ATKMKEALSS WLQDGVDGFQ 
241:	VRDVGKLANA SLYLAEWQNI TKNFSEDRLL IAGTASSDLQ QIVNILESTS DLLLTSSYLS 
301:	QPVFTGEHAE LLVIKYLNAT GSRWCSWSVS QAGLLTSFIP AQFLRLYQLL LFTLPGTPVF 
361:	SYGDELGLQA VALPGQPMEA PFMLWNESSN SQTSSPVSLN MTVKGQNEDP GSLLTQFRRL 
421:	SDLRGKERSL LHGDFDALSS SSGLFSYVRH WDQNERYLVV LNFQDVGLSA RVGASNLPAG 
481:	ISLPASANLL LSTDSTRLSR EEGTSLSLEN LSLNPYEGLL LQFPFVA