TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.A.9.1.1









rBAT
Eukaryota
Metazoa
rBAT of Oryctolagus cuniculus
*8.A.9.1.2









Neutral and basic amino acid transport protein rBAT (NBAT) (B(0,+)-type amino acid transport protein) (D2h)
Eukaryota
Metazoa
SLC3A1 of Homo sapiens
*8.A.9.2.1









4F2hc of 527 aas and 1 TMS.  The 4F2/CDC98 cell surface receptor is involved in internalization of beta-defensin 3 (Colavita et al. 2015).

Eukaryota
Metazoa
4F2hc of Rattus norvegicus
*8.A.9.2.2









The Slc3A2 (CD98hc; 4F2hc) accessory protein facilitates transport of amino acids and polyamines (putrescine/spermidine) (Uemura et al. 2008). 4F2hc stabilizes GLUT1 (2.A.1.1.28) and increase glucose transport activity (Ohno et al., 2011).  It forms a heterodimer with glycoprotein CD98 (LAT1; SLC7A5).  Contributes to tumorigenesis (Estrach et al. 2014).  CD98hc also modulates integrin signaling, plays a role in cell-to-cell fusion, and is essential for Brucella infection (Keriel et al. 2015). Hepatitis C virus (HCV) exploits SLC3A2 for viral propagation, and upregulation of SLC3A2 may contribute to HCV-mediated pathogenesis (Nguyen et al. 2018).

Eukaryota
Metazoa
SLC3A2 of Homo sapiens
*8.A.9.2.3









CD98hc, heavy chain of the heterodimeric CD998 (CG2791) amino acid transporter; involved in cell fusion, cell adhesion, TOR signalling, and amino acid transprot via LAT1 and LAT2 (see TC# 2.A.3.8.32) (Reynolds et al. 2009). CD98hc combines with one of six CD98lc proteins to regulate vascular smooth muscle cell proliferation in atherosclerosis (Baumer et al. 2017).

Eukaryota
Metazoa
CD98hc of Drosophila melanogaster (Fruit fly)
*8.A.9.3.1









Eukaryota
Metazoa
SPRM1hc of Schistosoma japonicum (Q5DDT5)