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8.A.91.1.4
Syntaxin-1A (Stx1; Stx1A; Sx1) of 288 aas.  Co-localizes with L-type Ca2+-channels (Cav1.2) in nano clusters at the plasma membrane (Sajman et al. 2017). Munc18 bridges the few syntaxin molecules residing on granules to the syntaxin cluster on the plasma membrane, suggesting that the number of syntaxins on vesicles determines docking and possibly fusion probability  (Borisovska 2018). Munc18-1 (P61764; see 1.F.1.1.3)), a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis, depends on two Munc18-1-interacting proteins called Mint1 or APBA1 (TC# 8.A.24.2.2) and Mint2 or SAPBA2 (TC# 8.A.24.2.3) (Okamoto and Südhof 1997).

Accession Number:Q16623
Protein Name:Syntaxin-1A aka STX1A
Length:288
Molecular Weight:33023.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

Genevestigator: Q16623
eggNOG: prNOG15580
HEGENOM: HBG717663
DIP: DIP-390N
RefSeq: NP_001159375.1    NP_004594.1   
Entrez Gene ID: 6804   
Pfam: PF05739    PF00804   
OMIM: 186590  gene
KEGG: hsa:6804   

Gene Ontology

GO:0030054 C:cell junction
GO:0005576 C:extracellular region
GO:0016021 C:integral to membrane
GO:0030672 C:synaptic vesicle membrane
GO:0019717 C:synaptosome
GO:0005484 F:SNAP receptor activity
GO:0006886 P:intracellular protein transport
GO:0050796 P:regulation of insulin secretion

References (11)

[1] “Cloning and sequence analysis of a cDNA encoding human syntaxin 1A, a polypeptide essential for exocytosis.”  Zhang R.-D.et.al.   7622072
[2] “Hemizygous deletion of the syntaxin 1A gene in individuals with Williams syndrome.”  Osborne L.R.et.al.   9311751
[3] “Refinement of the genomic structure of STX1A and mutation analysis in nondeletion Williams syndrome patients.”  Wu Y.-Q.et.al.   11977160
[4] “Novel isoform of syntaxin 1 is expressed in mammalian cells.”  Jagadish M.N.et.al.   9003414
[5] “Mapping of the human HPC-1/syntaxin 1A gene (STX1A) to chromosome 7 band q11.2.”  Nakayama T.et.al.   9177791
[6] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Expression analysis of the human HPC-1/syntaxin 1A, a gene deleted in Williams syndrome.”  Botta A.et.al.   10644452
[9] “Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion.”  Polgar J.et.al.   12130530
[10] “Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons.”  Su Q.et.al.   15459722
[11] “Phosphoproteomic analysis of synaptosomes from human cerebral cortex.”  DeGiorgis J.A.et.al.   15822905
Structure:
3hd7     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKDRTQELRT AKDSDDDDDV AVTVDRDRFM DEFFEQVEEI RGFIDKIAEN VEEVKRKHSA 
61:	ILASPNPDEK TKEELEELMS DIKKTANKVR SKLKSIEQSI EQEEGLNRSS ADLRIRKTQH 
121:	STLSRKFVEV MSEYNATQSD YRERCKGRIQ RQLEITGRTT TSEELEDMLE SGNPAIFASG 
181:	IIMDSSISKQ ALSEIETRHS EIIKLENSIR ELHDMFMDMA MLVESQGEMI DRIEYNVEHA 
241:	VDYVERAVSD TKKAVKYQSK ARRKKIMIII CCVILGIVIA STVGGIFA