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8.A.91.1.5
Syntaxin homologue, Sso1 of 290 aas and 1 C-terminal TMS (Ghaemmaghami et al. 2003). Membrane fusion transits through hemifusion, a condition in which the outer leaflets of the bilayers are mixed, but the inner leaflets are not. Hemifusion then proceeds to the fusion pore that connects the two internal contents. The TMSs of the fusion proteins play an essential role in the transition from hemifusion to the fusion pore. Sso1p, a target membrane t-SNARE involved in the trafficking from Golgi to plasma membrane. The TMS of Sso1p is a well-defined membrane spanning α-helix. There is an equilibrium between the monomers and the oligomers, and oligomerization is mainly mediated through the interaction at the N-terminal half of the TMS, whereas the C-terminal half is free of the tertiary interaction (Zhang and Shin 2006).

Accession Number:P32867
Protein Name:Protein SSO1
Length:290
Molecular Weight:33106.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type IV membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSYNNPYQLE TPFEESYELD EGSSAIGAEG HDFVGFMNKI SQINRDLDKY DHTINQVDSL 
61:	HKRLLTEVNE EQASHLRHSL DNFVAQATDL QFKLKNEIKS AQRDGIHDTN KQAQAENSRQ 
121:	RFLKLIQDYR IVDSNYKEEN KEQAKRQYMI IQPEATEDEV EAAISDVGGQ QIFSQALLNA 
181:	NRRGEAKTAL AEVQARHQEL LKLEKSMAEL TQLFNDMEEL VIEQQENVDV IDKNVEDAQL 
241:	DVEQGVGHTD KAVKSARKAR KNKIRCWLIV FAIIVVVVVV VVVPAVVKTR