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8.A.91.1.6
Syntaxin 3 (Stx3) of 289 aas with a C-terminal transmembrane anchor domain, is a  SNARE protein that is required for its membrane fusion activity.  Stx3 also functions as a nuclear regulator of gene expression. Alternative splicing creates a soluble isoform (Stx3S), lacking the transmembrane anchor which binds to the nuclear import factor RanBP5 (RAN-binding protein 5), targets to the nucleus, and interacts physically and functionally with several transcription factors (Giovannone et al. 2018).

Accession Number:Q13277
Protein Name:Syntaxin-3
Length:289
Molecular Weight:33155.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type IV membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKDRLEQLKA KQLTQDDDTD AVEIAIDNTA FMDEFFSEIE ETRLNIDKIS EHVEEAKKLY 
61:	SIILSAPIPE PKTKDDLEQL TTEIKKRANN VRNKLKSMEK HIEEDEVRSS ADLRIRKSQH 
121:	SVLSRKFVEV MTKYNEAQVD FRERSKGRIQ RQLEITGKKT TDEELEEMLE SGNPAIFTSG 
181:	IIDSQISKQA LSEIEGRHKD IVRLESSIKE LHDMFMDIAM LVENQGEMLD NIELNVMHTV 
241:	DHVEKARDET KKAVKYQSQA RKKLIIIIVL VVVLLGILAL IIGLSVGLN