TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.B.1.1.1









The α-neurotoxin BmK-MI precursor/x-ray structure known to 1.4 Å (Guan et al., 2004) (α-subfamily)
Eukaryota
Metazoa
BmK-MI of Mesobuthus (Buthus) martensii (84 aas; P45697)
*8.B.1.1.2









Markatoxin-III (MkTx-III) precursor
Eukaryota
Metazoa
MkTx-III of Mesobuthus (Buthus) martensii (85 aas; P59853)
*8.B.1.1.3









Non-toxic immunogenic venom protein, NTxp, precursor
Eukaryota
Metazoa
NTxp of Tityus serrulatus (84 aas; O77463)
*8.B.1.1.4









Depressant anti-insect-specific toxin 2 precursor, LqqIT2
Eukaryota
Metazoa
LqqIT2 of Leiurus quinquestriatus (82 aas; P19855)
*8.B.1.1.5









Excitatory insect-selective toxin 1 precursor, BmKIT1 (binds voltage independently to Na+ channels, shifting the voltage of activation to more negative potentials)
Eukaryota
Metazoa
BmKIT1 of Buthus martensii (88 aas; O61668)
*8.B.1.1.6









Pain-inducing α-toxin of 97 aas, CvIV4 (Rowe et al. 2011).  CvIV4 slowed the fast inactivation of Na(v)1.7, a Na+ channel expressed in peripheral pain-pathway neurons (nociceptors), but did not affect the Na(v)1.8-based sodium currents of these neurons. CvIV4 also slowed the fast inactivation of Na(v)1.2, Na(v)1.3 and Na(v)1.4. The effects of CvIV4 are similar to Old World α-toxins that target Na(v)1.7 (AahII, BmK MI, LqhIII, OD1).

Eukaryota
Metazoa
CvIV4 of Centruroides vittatus
*8.B.1.1.7









AahII; neurotoxin 2 of 85 aas. Scorpion α-toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals.

Eukaryota
Metazoa
AahII of Androctonus australis (Sahara scorpion)
*8.B.1.1.8









α-Neurotoxin of 67 aas from the yellow scorpion, LqhIII.  Binds voltage-independently at site-3 of sodium channels and inhibits the inactivation of the activated channels, modulating inactivation by hindering voltage-sensor movement, thereby blocking neuronal transmission (Ma et al. 2013). Dissociation is voltage-dependent. This alpha-like toxin is highly toxic to insects and competes with LqhaIT on binding to insect sodium channels. Differs from classical anti-mammalian alpha-toxins as it inhibits sodium channel inactivation in cell bodies of hippocampus brain neurons, on which the anti-mammalian Lqh2 is inactive, and is unable to affect Nav1.2 in the rat brain, on which Lqh2 is highly active (Rowe et al. 2011).

Eukaryota
Metazoa
LqhIII of Leiurus quinquestriatus hebraeus
*8.B.1.1.9









Drosomycin, an antimicrobial antifungal peptide of 70 aas and 1 N-terminal TMS.  Targets tetrodttoxin resistant Na+ channels (Zhu et al. 2010) including the Drosophila Na+ channel (Cohen et al. 2009).

Eukaryota
Metazoa
Drosomycin of Drosophila melanogaster
*8.B.1.2.1









Anti-crustacean-specific toxin 1 (β-subfamily)
Eukaryota
Metazoa
Anti-crustacean-specific toxin 1 of Centruroides limpidus (66 aas; P45667)