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The α-neurotoxin BmK-MI precursor/x-ray structure known to 1.4 Å (Guan et al., 2004) (α-subfamily)

Accession Number:P45697
Protein Name:BmK I aka BmK-M1
Molecular Weight:9496.00
Species:Mesobuthus martensii (Manchurian scorpion) (Buthus martensii) [34649]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF00537   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019871 F:sodium channel inhibitor activity
GO:0006952 P:defense response
GO:0009405 P:pathogenesis

References (10)

[1] “The cDNA and genomic DNA sequences of a mammalian neurotoxin from the scorpion Buthus martensii Karsch.”  Xiong   9248001
[2] “Two neurotoxins (BmK I and BmK II) from the venom of the scorpion Buthus martensi Karsch: purification, amino acid sequences and assessment of specific activity.”  Ji   8896191
[3] “Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensi Karsch venom.”  Goudet   11322948
[4] “Exploration of the functional site of a scorpion alpha-like toxin by site-directed mutagenesis.”  Wang   12705833
[5] “Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited.”  Sun   12692120
[6] “Molecular basis of the mammalian potency of the scorpion alpha-like toxin, BmK M1.”  Liu   15677695
[7] “A series of bioactivity-variant neurotoxins from scorpion Buthus martensii Karsch: purification, crystallization and crystallographic analysis.”  Li   10089445
[8] “Crystal structures of two alpha-like scorpion toxins: non-proline cis peptide bonds and implications for new binding site selectivity on the sodium channel.”  He   10493862
[9] “Structural mechanism governing cis and trans isomeric states and an intramolecular switch for cis/trans isomerization of a non-proline peptide bond observed in crystal structures of scorpion toxins.”  Guan   15321715
[10] “Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1.”  Ye   16209876
1DJT   1SN1   1T7A   1T7B   1T7E   1ZU3   1ZUT   1ZVE   1ZVG   1ZYV   [...more]

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FASTA formatted sequence