TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.B.1.1.4
Depressant anti-insect-specific toxin 2 precursor, LqqIT2

Accession Number:P19855
Protein Name:Depressant insect toxin 2 aka LqqIT2
Length:82
Molecular Weight:9100.00
Species:Leiurus quinquestriatus quinquestriatus (Egyptian scorpion) [6885]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF00537   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019871 F:sodium channel inhibitor activity
GO:0006952 P:defense response
GO:0009405 P:pathogenesis

References (5)

[1] “Three polymorphic genes encoding a depressant toxin from the Egyptian scorpion Leiurus quinquestriatus quinquestriatus.”  Zaki T.I.et.al.   12467668
[2] “Primary structure of scorpion anti-insect toxins isolated from the venom of Leiurus quinquestriatus quinquestriatus.”  Kopeyan C.et.al.   2311768
[3] “Functional duality and structural uniqueness of depressant insect-selective neurotoxins.”  Zlotkin E.et.al.   2029523
[4] “Depressant insect selective neurotoxins from scorpion venom: chemistry, action, and gene cloning.”  Zlotkin E.et.al.   8431601
[5] “The depressant scorpion neurotoxin LqqIT2 selectively modulates the insect voltage-gated sodium channel.”  Bosmans F.et.al.   15733572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKLLLLLIVS ASMLIESLVN ADGYIRKRDG CKLSCLFGNE GCNKECKSYG GSYGYCWTWG 
61:	LACWCEGLPD DKTWKSETNT CG