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8.B.1.1.5
Excitatory insect-selective toxin 1 precursor, BmKIT1 (binds voltage independently to Na+ channels, shifting the voltage of activation to more negative potentials)

Accession Number:O61668
Protein Name:BmKIT1 aka Bm32-VI
Length:88
Molecular Weight:9767.00
Species:Mesobuthus martensii (Manchurian scorpion) (Buthus martensii) [34649]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF00537   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019871 F:sodium channel inhibitor activity
GO:0006952 P:defense response
GO:0009405 P:pathogenesis

References (4)

[1] “The cDNA sequence of an excitatory insect selective neurotoxin from the scorpion Buthus martensi Karsch.”  Xiong Y.-M.et.al.   10078863
[2] “Amino acid sequence of an excitatory insect-selective toxin (BmK IT) from venom of the scorpion Buthus martensi Karsch.”  Ji Y.H.et.al.   8068186
[3] “Sequence and electrophysiological characterization of two insect-selective excitatory toxins from the venom of the Chinese scorpion Buthus martensi.”  Escoubas P.et.al.   11042276
[4] “NMR solution structure of BmK-betaIT, an excitatory scorpion beta-toxin without a 'hot spot' at the relevant position.”  Tong X.et.al.   16970911
Structure:
1WWN     

External Searches:

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Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKFFLIFLVI FPIMGVLGKK NGYAVDSSGK VSECLLNNYC NNICTKVYYA TSGYCCLLSC 
61:	YCFGLDDDKA VLKIKDATKS YCDVQIIG