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8.B.1.1.8
α-Neurotoxin of 67 aas from the yellow scorpion, LqhIII.  Binds voltage-independently at site-3 of sodium channels and inhibits the inactivation of the activated channels, modulating inactivation by hindering voltage-sensor movement, thereby blocking neuronal transmission (Ma et al. 2013). Dissociation is voltage-dependent. This alpha-like toxin is highly toxic to insects and competes with LqhaIT on binding to insect sodium channels. Differs from classical anti-mammalian alpha-toxins as it inhibits sodium channel inactivation in cell bodies of hippocampus brain neurons, on which the anti-mammalian Lqh2 is inactive, and is unable to affect Nav1.2 in the rat brain, on which Lqh2 is highly active (Rowe et al. 2011).

Accession Number:P56678
Protein Name:Alpha-like toxin Lqh3
Length:67
Molecular Weight:7057.00
Species:Leiurus quinquestriatus hebraeus (Yellow scorpion) [6884]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Structure:
1BMR   1FH3     

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FASTA formatted sequence
1:	VRDGYIAQPE NCVYHCFPGS SGCDTLCKEK GGTSGHCGFK VGHGLACWCN ALPDNVGIIV 
61:	EGEKCHS