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8.B.1.2.2
Beta-anti-mammalian scorpian toxin, Css4 of 87 aas and 1 N-terminal TMS.  Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials, thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (Cestèle et al. 2001). This toxin is active only on Na+ channels in mammals (Cestèle et al. 1998). Binding results from electrostatic interactions in domain II of the Na+ channels (Mantegazza and Cestèle 2005).  

Accession Number:P60266
Protein Name:Beta-mammal toxin Css4
Length:87
Molecular Weight:9785.00
Species:Centruroides suffusus (Durango bark scorpion) [6880]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

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  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNSLLMITAC LALVGTVWAK EGYLVNSYTG CKFECFKLGD NDYCLRECRQ QYGKGSGGYC 
61:	YAFGCWCTHL YEQAVVWPLP NKTCNGK