TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.B.10.1.1









Psalmotoxin-1 (PcTx1) 40 aas (Diochot et al., 2007).  The Pi theraphotoxin Pc1a potently and selectively blocks the acid-sensing ion channel ASIC1a/ACCN2. The blockade is rapid and reversible. Psalmotoxin 1 loses its capacity to block ASIC1a/ACCN2 as soon as this subunit is associated with another member of the family (ASIC2a/ACCN1 or ASIC3/ACCN3). The toxin can distinguish between the two ASIC1/ACCN2 splice variants ASIC1a/ACCN2 and ASIC1b/ACCN2 (Chagot et al. 2004).  The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.  The 3-D structure is known (Chagot et al. 2005). This "gating blocker" mainly regulate ASIC1a gating through hydrogen bonds, which can affect the relative positions of several key domains in ASIC1a, and a long-range conformational change path was determined, which is composed of beta1, beta2, beta10, alpha6, alpha7, beta11 and beta12 in ASIC1a (Yu et al. 2017).

Eukaryota
Metazoa
PcTx1 of Psalmopoeus cambridgei (P60514)
*8.B.10.1.2









Unprocessed precursor of U34-theraphotoxin-Cj1a; Jingzhaotoxin-74; JzTx-74 of 134 aas.  The processed form is secreted.  Belongs to the MIT-like AcTx family.

Eukaryota
Metazoa
JzTx-74 of Chilobrachys guangxiensis (Chinese earth tiger tarantula) (Chilobrachys jingzhao)
*8.B.10.1.3









U33-theraphotoxin-Cj1a; Jingzhaotoxin-69, JzTx69, or 124 aas.

Eukaryota
Metazoa
JzTx69 of Chilobrachys guangxiensis
*8.B.10.1.4









U1-hexatoxin-Hsp201e; Atracotoxin-Hs20f7496

Eukaryota
Metazoa
Atracotoxin of Hadronyche sp. 20
*8.B.10.1.5









Hainantoxin-XIV-4 of 84 aas. Of the MIT-like AcTx family.

Eukaryota
Metazoa
Hainantoxin-XIV-4 of Haplopelma hainanum
*8.B.10.2.1









M-Lycotoxin Hc1a; Lycotoxin I of 25 aas.  Forms pores that permeabilize the cell membrane and promotes efflux of calcium from synaptosomes.  It also causes hemolysis and dissipates voltage gradients across muscle membrane. Potently inhibits the growth of bacteria, yeast and Leishmania. Is lethal to lepidopteran larvae. May function both in the prey capture strategy and in protection from infectious organisms arising from prey ingestion (Hughes et al. 2008; Adão et al. 2008).

Eukaryota
Metazoa
Lycotoxin I of Hogna (Lycosa) carolinensis (wolf spider)
*8.B.10.2.2









Short cationic peptide 5a, SCP5a of 24 aas. 46% identical to M-Lycotoxin Hc1a (8.B.10.2.1)

Eukaryota
Metazoa
SCP5a of Cupiennius salei (spider)