TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.B.12.1.1









The spider toxin Tx2-5 (Matavel et al., 2009).
Eukaryota
Metazoa
Tx2-5 of Phoneutria nigriventer (P29424)
*8.B.12.1.2









Omega-ctenitoxin-Pn4a, CnTx-Pn4a; neurotoxin Tx3-6; α1-β toxin of 90 aas

Eukaryota
Metazoa
Tx3.6 of Phoneutria nigriventer
*8.B.12.1.3









Hainantoxin XV-2, HnTx-XV-2 of 117 aas.

Eukaryota
Metazoa
HnTx-XV-2 of Haplopelma hainanum
*8.B.12.1.4









Cystine knot toxin of 114 aas

Eukaryota
Metazoa
Cystine knot toxin of Dolomedes mizhoanus
*8.B.12.1.5









Omega-ctenitoxin-Pn4a of 90 aas and 1 TMS.  The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. It is a potent blocker of high voltage-activated calcium channels, acting mainly on P/Q-type (Cav2.1/CACNA1A) calcium channels and with a minor effect on L- (Cav1/CACNA1) and N-type (Cav2.2/CACNA1B) calcium channels (Vieira et al. 2005). It blocks glutamate release in synaptic transmission mediated by calcium channels (Vieira et al. 2003). The toxin also inhibits the KCl-induced increase of intrasynaptosomal free calcium (Souza et al. 2008).

Eukaryota
Metazoa
Toxin of Phoneutria nigriventer (Brazilian armed spider)
*8.B.12.1.6









Spiderine-1a of 166 aas and 1 TMS.  It has antimicrobial, insecticidal, cytolytic and cytotoxic activity, and is active against E. coli, E. faecalis, B. subtilis, A. globiformis, P. aeruginosa and S. aureus in submicromolar or low micromolar ranges. It also lyses human erythrocytes and kills HeLA and A549 cells (Vassilevski et al. 2013).

Eukaryota
Metazoa
Spiderine of Oxyopes takobius (Lynx spider) (Oxyopes foliiformis)