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8.B.13.1.1
Kalicludine 3 toxin (59 aas) There are three types, AsKCl-3, which block Kv1.2 K+ channels. Shows 48% identity (e-11) with a central region of an Alzheimer's disease amyloid A4 homologue (1.C.50.1.1).

Accession Number:Q9TWF8
Protein Name:Kunitz-type proteinase inhibitor kalicludin-3
Length:59
Molecular Weight:6738.00
Species:Anemonia sulcata (Mediterranean snakelocks sea anemone) [6108]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF00014   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042151 C:nematocyst
GO:0019870 F:potassium channel inhibitor activity
GO:0004867 F:serine-type endopeptidase inhibitor activity
GO:0009405 P:pathogenesis

References (1)

[1] “Kalicludines and kaliseptine. Two different classes of sea anemone toxins for voltage sensitive K+ channels.”  Schweitz H.et.al.   7559645

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	INGDCELPKV VGRCRARFPR YYYNLSSRRC EKFIYGGCGG NANNFHTLEE CEKVCGVRS