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8.B.14.1.2
ShK potassium channel toxin (3-d structure known (1BEI; 1C2U_A))

Accession Number:P29187
Protein Name:Potassium channel toxin ShK
Length:35
Molecular Weight:4061.00
Species:Stoichactis helianthus (Carribean sea anemone) [6123]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF01549   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042151 C:nematocyst
GO:0019870 F:potassium channel inhibitor activity
GO:0009405 P:pathogenesis

References (6)

[1] “Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus.”  Castaneda O.et.al.   7660365
[2] “Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone.”  Tudor J.E.et.al.   8599755
[3] “ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.”  Kalman K.et.al.   9830012
[4] “Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus.”  Castaneda O.et.al.   7660365
[5] “Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone.”  Tudor J.E.et.al.   8599755
[6] “ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.”  Kalman K.et.al.   9830012
Structure:
1BEI   1C2U   1ROO   2K9E   4LFQ   4LFS   4Z7P     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	RSCIDTIPKS RCTAFQCKHS MKYRLSFCRK TCGTC