TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.B.14.1.1









Sea anemone Class 1 toxin, BgK of 37 aas (blocks channels containing Kv1 subunits); the 3-d structure known (1BGKA) (Aneiros et al. 1993).

Eukaryota
Metazoa
Bgk of Bunodosoma granuliferum (Red warty sea anemone)
*8.B.14.1.2









ShK potassium channel toxin (3-d structure known (1BEI; 1C2U_A))

Eukaryota
Metazoa
ShK Toxin of Stoichactis helianthus (P29187)
*8.B.14.1.3









Sea anemone voltage-sensitive K+ channel inhibitor, Actitoxin Aeq1a; of 36 aas.  Also bolcks α-dendrotoxin binding (Minagawa et al. 1998).

Eukaryota
Metazoa
ShKT of Actina equina Beadlet anemone)
*8.B.14.1.4









Uncharacterized protein of 99 aas.

Eukaryota
Metazoa
UP of Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
*8.B.14.1.5









ShTK domain protein of 106 aas.

Eukaryota
Metazoa
ShTK domain protein of Necator americanus (Human hookworm)
*8.B.14.1.6









K+ channel blocker of 74 aas (Jouiaei et al. 2015).  Inhibits voltage-gated potassium channels (Kv1.2/KCNA2) and facilitates acetylcholine release at the avian neuromuscular junction.

Eukaryota
Metazoa
Toxin of Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)
*8.B.14.2.1









Matrix metalloprotease 23 (MMP23), with a C-terminal K channel blocking Toxin Domain, TxD (residues 254 - 290; 37 aas). The NMR structure of the 37 aa toxin domain is available (2K72_A) (Rangaraju et al., 2010).

Eukaryota
Metazoa
MMP23 of Mus musculus (O88676)
*8.B.14.2.2









Matrix metalloproteinase-23, MMP23B, (ADAM23, MMP21 or MMP22) of 390 aas. It regulates the surface expression of several potassium channels by retaining them in the endoplasmic reticulum (Ohnishi et al. 2001; Costa et al. 2015). ADAM22 and ADAM23 have opposite effects on Kv1.1/Kv1.4 currents, ADAM23 inhbiting and ADAM22 activating. The relative expression of these proteins may shape the expression of K+ currents in different neuronal membrane domains (Lancaster et al. 2019).

 

Eukaryota
Metazoa
ADAM23 of Homo sapiens
*8.B.14.3.1









Bowman-Birk type proteinase inhibitor DE-3 of 76 aas.  It is a serine protease inhibitor.

Eukaryota
Viridiplantae
DE-3 of Macrotyloma axillare