TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.B.16.1.1









Maurocalcine (MCa) of the scorpion.  The 3-d structure is known (1C6W_A) (Mabrouk et al., 2007).

Eukaryota
Metazoa
Maurocalcin of Maurus palmatus (P60254)
*8.B.16.1.2









Egg protein of 92 aas

Eukaryota
Metazoa
Egg protein of Scizosoma japonicum (blood fluke)
*8.B.16.1.3









Hadrucalcin of 74 aas. A knottin. Activates both skeletal ryanodine receptors (RYR1) and cardiac ryanodine receptors (RYR2) by inducing a long-lasting subconductance state, rapidly permeating the external membrane of cardiomyocytes and inducing calcium release from intracellular stores. Acts synergistically with caffeine (Schwartz et al. 2009).

Eukaryota
Metazoa
Hadrucalcin of Hadrurus gertschi
*8.B.16.1.4









Ω-hexatosin-Hv1e (Ω-Alracotoxin-Hv1e), a knottin of 37 aas.  The 3-d structure of a synthetic construct of similar sequence is availalbe (1HVW_A).

Eukaryota
Metazoa
hexatoxin of Hadronyche versuta or Atrax versutus (funnel web spider)
*8.B.16.2.1









Gamma-conotoxin PnVIIA of 80 aas and 1 TMS. It may act on voltage-gated non-specific cation pacemaker channels (HCN). It triggers depolarization and firing of action potential bursts in the caudodorsal neurons of lymnaea. This effect is due to activation or enhancement of a slow inward cation current that may underlie endogenous bursting activity of these neurons (Fainzilber et al. 1998).

Eukaryota
Metazoa
γ-conotoxin of Conus pennaceus (Feathered cone) (Conus episcopus)
*8.B.16.2.2









Gamma-conotoxin-like TeA53 of 81 aas.

Eukaryota
Metazoa
γ-conotoxin of Conus textile (Cloth-of-gold cone)