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8.B.17.1.3
Anthopleurin-A, AP-A, a heart stimulant; binds voltage-gated Na+ channels (structure known) (Frazão et al. 2012).

Accession Number:P01530
Protein Name:Anthopleurin-A
Length:49
Molecular Weight:5138.00
Species:Anthopleura xanthogrammica (Giant green sea anemone) [6112]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF00706   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042151 C:nematocyst
GO:0019871 F:sodium channel inhibitor activity
GO:0009405 P:pathogenesis
GO:0009966 P:regulation of signal transduction

References (4)

[1] “Amino acid sequence of the Anthopleura xanthogrammica heart stimulant, anthopleurin A.”  Tanaka M.et.al.   13806
[2] “Cardiotonic polypeptides from Anthopleura xanthogrammica (Brandt) and A. elegantissima (Brandt).”  Norton T.R.et.al.   6108877
[3] “Sequential 1H-NMR assignments and secondary structure of the sea anemone polypeptide anthopleurin-A.”  Mabbut B.C.et.al.   1968006
[4] “Three-dimensional structure in solution of the polypeptide cardiac stimulant anthopleurin-A.”  Pallaghy P.K.et.al.   7893675
Structure:
1AHL     

External Searches:

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FASTA formatted sequence
1:	GVSCLCDSDG PSVRGNTLSG TLWLYPSGCP SGWHNCKAHG PTIGWCCKQ