TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.B.28.1.1









Mu-conotoxin (Mu-conopeptide) SIIIA of 73 aas.  Inhibits both Na+ and K+ channels specifically; thus Kv1.1 and Kv1.6 are inhibited, but other K+ channels tested were not (Leipold et al. 2016).  Of Na+ channels, this toxin moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, rNav1.3/SCN3A, rNav1.4/SCN4A, and mNav1.6/SCN8A (Wang et al. 2006; Yao et al. 2008; Bulaj et al. 2005).

Eukaryota
Metazoa
Conotoxin SIIIA of Conus striatus (Striated cone)
*8.B.28.1.2









Conotoxin (conopeptide) PIIIA of 73 aas. Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently but reversibly blocks rNav1.4/SCN4A and moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, rNav1.3/SCN3A, mNav1.6/SCN8A, and h/rNav1.7/SCN9A. The block of SCN1A, SCN2A, and SCN8A is modified when beta-subunits are coexpressed with alpha subunits. Hence, blocks of channels containing beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing beta-2 and beta-4 are less potent (also compared to channels without beta subunits). This peptide causes flaccid paralysis in both mice and fish (Holford et al. 2009; Favreau et al. 2012; Zhang et al. 2013; Leipold et al. 2016).

Eukaryota
Metazoa
Conotoxin PIIIA of Conus purpurascens (Purple cone)
*8.B.28.1.3









Conotoxin (conopeptide) Mu-GIIIA of 74 aas. Specifically blocks skeletal muscle voltage-gated sodium (NaV1.4) channels (Leipold et al. 2016).

Eukaryota
Metazoa
Conotoxin Mu-GIIIA of Conus geographus (Geography cone) (Nubecula geographus)
*8.B.28.1.4









Mu-conotoxin KIIIA of 18 aas. This toxin potently blocks rNav1.2/SCN2A and rNav1.4/SCN4A but also moderately blocks rNav1.1/SCN1A, rNav1.3/SCN3A, rNav1.5/SCN5A, mNav1.6/SCN8A, and rNav1.7/SCN9A. On rNav1.2/SCN2A, it produces a block that is only partially reversible. The block of SCN9A is modified when beta-subunits are coexpressed with the alpha subunit (McArthur et al. 2011; Zhang et al. 2013).

Eukaryota
Metazoa
Mu-conotoxin KIIIA of Conus kinoshitai (Kinoshita's cone)
*8.B.28.1.5









M superfamily MLKM group conopeptide Vx3-A01 of 70 aas and 1 N-terminal TMS

Eukaryota
Metazoa
M superfamily MLKM group conopeptide Vx3-A01 of Conus vexillum (Flag cone)
*8.B.28.1.6









M-superfamily conotoxin of 71 aas and 1 TMS.

Eukaryota
Metazoa
M-superfamily conotoxin of Conus ebraeus (Hebrew cone)
*8.B.28.1.7









Conotoxin Vn.MLKM-04 of 69 aas and 1 TMS.

Eukaryota
Metazoa
Cnotoxin VNMLKM-04 of Conus ventricosus (Mediterranean cone)