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8.B.28.1.2
Conotoxin (conopeptide) PIIIA of 73 aas. Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently but reversibly blocks rNav1.4/SCN4A and moderately blocks rNav1.1/SCN1A, rNav1.2/SCN2A, rNav1.3/SCN3A, mNav1.6/SCN8A, and h/rNav1.7/SCN9A. The block of SCN1A, SCN2A, and SCN8A is modified when beta-subunits are coexpressed with alpha subunits. Hence, blocks of channels containing beta-1 and beta-3 subunits are more potent (compared to channels without beta subunits), whereas blocks of channels containing beta-2 and beta-4 are less potent (also compared to channels without beta subunits). This peptide causes flaccid paralysis in both mice and fish (Holford et al. 2009; Favreau et al. 2012; Zhang et al. 2013; Leipold et al. 2016).

Accession Number:P58925
Protein Name:Mu-conotoxin PIIIA
Length:73
Molecular Weight:8334.00
Species:Conus purpurascens (Purple cone) [41690]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

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FASTA formatted sequence
1:	MSKLGVLLTI CLLLFPITAL PMDGDQPADR LAERMQDNIS SEEHPFEKRQ RLCCGFPKSC 
61:	RSRQCKPHRC CGR