TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.B.28.1.8
Iota-conotoxin of 69 aas and 1 N-terminal TMS. Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin enhances tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons (Wang et al. 2009).

Accession Number:Q2I2Q5
Protein Name:Iota-conotoxin LtIIIA
Length:69
Molecular Weight:7931.00
Species:Conus litteratus (Lettered cone) [89445]
Location1 / Topology2 / Orientation3: Secreted1
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MLKMGVLLFT FLVLFPLTTL ELDTDRPVER HAAIKQDLKP QERRGIRLHA PRDECCEPQW 
61:	CDGACDCCS