TCDB is operated by the Saier Lab Bioinformatics Group

8.B.35.  The Conantokin (Conantokin) Family 

Conus venoms contain a diversity of pharmacologically active small peptides. Their targets are ion channels and receptors in the neuromuscular system. The venom of Conus geographus contains high-affinity peptides that act on voltage-sensitive calcium channels, sodium channels, N-methyl-D-aspartate (NMDA) receptors, acetylcholine receptors, and vasopressin receptors; many more peptides with still uncharacterized receptor targets are present in this venom. It seems that the Conus species (approximately 500 known) will each use a distinctive assortment of peptides and that the pharmacological diversity in Conus venoms may be comparable to that of plant alkaloids or secondary metabolites of microorganisms. The cone snails may generate this diverse spectrum of venom peptides by a "fold-lock-cut" synthetic pathway. These peptides are specific enough to discriminate effectively between closely related receptor subtypes and can be used for structure-function correlations (Olivera et al. 1990).

References associated with 8.B.35 family:

Liu, Z., H. Li, N. Liu, C. Wu, J. Jiang, J. Yue, Y. Jing, and Q. Dai. (2012). Diversity and evolution of conotoxins in Conus virgo, Conus eburneus, Conus imperialis and Conus marmoreus from the South China Sea. Toxicon 60: 982-989. 22781954
Olivera, B.M., J. Rivier, C. Clark, C.A. Ramilo, G.P. Corpuz, F.C. Abogadie, E.E. Mena, S.R. Woodward, D.R. Hillyard, and L.J. Cruz. (1990). Diversity of Conus neuropeptides. Science 249: 257-263. 2165278