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8.B.4.1.7
δ-conotoxin, TxVIA of 78 aas and 1 TMS.  Binds to the extracellular sides of voltage-gated sodium channels (Nav) and inhibits the inactivation process. Binding of this toxin is calcium-dependent but not voltage-dependent.  It is important in mollusks for the paralysis of prey.  The 3-d solution structure is known (Kohno et al. 2002).

Accession Number:P18511
Protein Name:Delta-conotoxin TxVIA
Length:78
Molecular Weight:8760.00
Species:Conus textile (Cloth-of-gold cone) [6494]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Structure:
1FU3     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKLTCMMIVA VLFLTAWTFA TADDPRNGLG NLFSNAHHEM KNPEASKLNK RWCKQSGEMC 
61:	NLLDQNCCDG YCIVLVCT