8.B.4.1.7 δ-conotoxin, TxVIA of 78 aas and 1 TMS. Binds to the extracellular sides of voltage-gated sodium
channels (Nav) and inhibits the inactivation process. Binding of this
toxin is calcium-dependent but not voltage-dependent. It is important in mollusks for the paralysis of prey. The 3-d solution structure is known (Kohno et al. 2002).
|
Accession Number: | P18511 |
Protein Name: | Delta-conotoxin TxVIA |
Length: | 78 |
Molecular Weight: | 8760.00 |
Species: | Conus textile (Cloth-of-gold cone) [6494] |
Number of TMSs: | 1 |
Location1 / Topology2 / Orientation3: |
Secreted1 |
Substrate |
NONE |
---|
1: MKLTCMMIVA VLFLTAWTFA TADDPRNGLG NLFSNAHHEM KNPEASKLNK RWCKQSGEMC
61: NLLDQNCCDG YCIVLVCT