TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family

T-2 (chi -or lambda-)conotoxin MrIA precursor (61aas) (inhibitor of the human norepinephrine transporter) (Lovelace et al., 2006). These toxins have a unique disulfide arrangement and folding pattern, and they contain 4-trans hydroxyproline (Balaji et al. 2000).

Accession Number:P58808
Protein Name:T-2-conotoxin MrIA
Molecular Weight:6499.00
Species:Conus marmoreus (Marble cone) [42752]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Gene Ontology

GO:0005576 C:extracellular region
GO:0009405 P:pathogenesis

References (7)

[1] “Isolation and characterization of a novel conus peptide with apparent antinociceptive activity.”  McIntosh   10900201
[2] “Lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus.”  Balaji   10988292
[3] “Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter.”  Sharpe   11528421
[4] “Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship.”  Sharpe   12885787
[5] “Chi-conopeptide MrIA partially overlaps desipramine and cocaine binding sites on the human norepinephrine transporter.”  Bryan-Lluka   12837768
[6] “Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain.”  Nielsen   16154696
[7] “Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter.”  Nilsson   15931669
2EW4   2J15     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)


Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
61:	C