TCDB is operated by the Saier Lab Bioinformatics Group

8.B.40.  The Conotoxin (Con-ikot-ikot/Conopressin/Conophysin/Conokunitzin/ConoCAP) (CCCCC) Family

  The precursor proteins of this family mostly consist of large conotoxins of ~ 125 aas with an N-terminal TMS. They have been named as noted in the title (Robinson and Norton 2014).

This family belongs to the: Conotoxin Superfamily.

References associated with 8.B.40 family:

Peng, C., G. Yao, B.M. Gao, C.X. Fan, C. Bian, J. Wang, Y. Cao, B. Wen, Y. Zhu, Z. Ruan, X. Zhao, X. You, J. Bai, J. Li, Z. Lin, S. Zou, X. Zhang, Y. Qiu, J. Chen, S.L. Coon, J. Yang, J.S. Chen, and Q. Shi. (2016). High-throughput identification of novel conotoxins from the Chinese tubular cone snail (Conus betulinus) by multi-transcriptome sequencing. Gigascience 5: 17. 27087938
Robinson, S.D. and R.S. Norton. (2014). Conotoxin gene superfamilies. Mar Drugs 12: 6058-6101. 25522317
Walker, C.S., S. Jensen, M. Ellison, J.A. Matta, W.Y. Lee, J.S. Imperial, N. Duclos, P.J. Brockie, D.M. Madsen, J.T. Isaac, B. Olivera, and A.V. Maricq. (2009). A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. Curr. Biol. 19: 900-908. 19481459