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8.B.5.3.3
Heteroscodratoxin-1 (HMTx1) of the tarantula (35 aas) (blocks the voltage-gated K+ channels: Kv2.1 (KCNB1), Kv2.2 (KCNB2), Kv4.1 (KCND1), Kv4.2 (KCND2) and Kv4.3 (KCND3) causing convulsions and death in mice (Escoubas et al, 2002))

Accession Number:P60992
Protein Name:HmTx1
Length:35
Molecular Weight:4003.00
Species:Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider) [268413]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF07740   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019870 F:potassium channel inhibitor activity
GO:0009405 P:pathogenesis

References (1)

[1] “Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies.”  Escoubas P.et.al.   12065754

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	ECRYLFGGCS STSDCCKHLS CRSDWKYCAW DGTFS