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8.B.5.3.4
Huwentoxin-5 (HwTx5) precursor (86 aas) (insecticidal neurotoxin, Knottin-type; Diao et al., 2003; Zhang et al., 2003)

Accession Number:P61104
Protein Name:HwTx5
Length:86
Molecular Weight:9659.00
Species:Ornithoctonus huwena (Chinese bird spider) (Selenocosmia huwena) [29017]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF07740   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019855 F:calcium channel inhibitor activity
GO:0019870 F:potassium channel inhibitor activity
GO:0009405 P:pathogenesis

References (3)

[1] “cDNA sequence analysis of seven peptide toxins from the spider Selenocosmia huwena.”  Diao J.et.al.   14757201
[2] “Huwentoxin-V, a novel insecticidal peptide toxin from the spider Selenocosmia huwena, and a natural mutant of the toxin: indicates the key amino acid residues related to the biological activity.”  Zhang P.-F.et.al.   12893056
[3] “Inhibition of insect calcium channels by huwentoxin-V, a neurotoxin from Chinese tarantula Ornithoctonus huwena venom.”  Deng M.et.al.   18234186

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKSIVFVALF GLALLAVVCS ASEDAHKELL KEVVRAMVVD KTDAVQAEER ECRWYLGGCS 
61:	QDGDCCKHLQ CHSNYEWCVW DGTFSK