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8.B.5.3.5
Jingzhaotoxin-11 (JzTx11) precursor (86 aas) (Inhibits K+ and Na+ channels (e.g., Kv2.1, Kv4.1, Kv4.2, and Kv1.5)(Structure known: Liao et al., 2006))

Accession Number:P0C247
Protein Name:JzTx11
Length:86
Molecular Weight:9527.00
Species:Chilobrachys jingzhao (Chinese spider) [278060]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF07740   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019870 F:potassium channel inhibitor activity
GO:0019871 F:sodium channel inhibitor activity
GO:0009405 P:pathogenesis

References (1)

[1] “Solution structure and functional characterization of Jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels.”  Liao Z.et.al.   17176080
Structure:
2A2V     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MKVSVLITLA VLGVMFVWAS AAELEERGSD QRDSPAWLKS MERIFQSGER ECRKMFGGCS 
61:	VDSDCCAHLG CKPTLKYCAW DGTFGK