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8.B.5.3.6
Hantotoxin-1 (HATx1) (35 aas) (Inhibits K+ and Ca2+ channels, e.g., Kv2.1, Kv4.2 and Cav2.1); (Structure known: Takahashi et al., 2000)

Accession Number:P56852
Protein Name:Hanatoxin-1 aka HaTx1
Length:35
Molecular Weight:4121.00
Species:Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata) [432528]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF07740   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019855 F:calcium channel inhibitor activity
GO:0019870 F:potassium channel inhibitor activity
GO:0009405 P:pathogenesis

References (7)

[1] “An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula.”  Swartz K.J.et.al.   7576642
[2] “Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites.”  Swartz K.J.et.al.   9136774
[3] “Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels.”  Swartz K.J.et.al.   9136775
[4] “Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels.”  Li-Smerin Y.et.al.   9671721
[5] “Voltage-sensor activation with a tarantula toxin as cargo.”  Phillips L.R.et.al.   16094370
[6] “Gating modifier peptides as probes of pancreatic beta-cell physiology.”  Herrington J.et.al.   17101164
[7] “Solution structure of hanatoxin1, a gating modifier of voltage-dependent K(+) channels: common surface features of gating modifier toxins.”  Takahashi H.et.al.   10731427
Structure:
1D1H     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	ECRYLFGGCK TTSDCCKHLG CKFRDKYCAW DFTFS