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8.B.5.3.7
ω-grammotoxin, SIA. Blocks P/Q type voltage-dependent calcium channels, Cav2.1 (Ono et al., 2011).

Accession Number:P60590
Protein Name:Omega-theraphotoxin-Gr1a
Length:36
Molecular Weight:4117.00
Species:Grammostola rosea (Chilean rose tarantula) [432528]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF07740   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019855 F:calcium channel inhibitor activity
GO:0019870 F:potassium channel inhibitor activity
GO:0009405 P:pathogenesis

References (5)

[1] “Isolation and pharmacological characterization of omega-grammotoxin SIA, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses.”  Lampe R.A.et.al.   8394998
[2] “Complete and reversible block by omega-grammotoxin SIA of glutamatergic synaptic transmission between cultured rat hippocampal neurons.”  Piser T.M.et.al.   8848236
[3] “Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin omega-grammotoxin-SIA.”  McDonough S.I.et.al.   9415720
[4] “Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca2+ and K+ channels.”  Li-Smerin Y.et.al.   9671721
[5] “Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel.”  Takeuchi K.et.al.   12162963
Structure:
1KOZ     

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FASTA formatted sequence
1:	DCVRFWGKCS QTSDCCPHLA CKSKWPRNIC VWDGSV