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8.B.6.1.1
Ω-agatoxin IVA

Accession Number:P30288
Protein Name:Ω-agatoxin IVA
Length:48
Molecular Weight:5210.00
Species:Agelenopsis aperta (Funnel-web spider) [6908]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF02819   

Gene Ontology

GO:0005576 C:extracellular region
GO:0042734 C:presynaptic membrane
GO:0019855 F:calcium channel inhibitor activity
GO:0009405 P:pathogenesis
GO:0007268 P:synaptic transmission

References (3)

[1] “P-type calcium channels blocked by the spider toxin omega-Aga-IVA.”  Mintz I.M.et.al.   1311418
[2] “Three-dimensional solution structure of the calcium channel antagonist omega-agatoxin IVA: consensus molecular folding of calcium channel blockers.”  Kim J.I.et.al.   7623383
[3] “Structure-activity relationships for P-type calcium channel-selective omega-agatoxins.”  Reily M.D.et.al.   7773772
Structure:
1IVA   1OAV   1OAW     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	KKKCIAKDYG RCKWGGTPCC RGRGCICSIM GTNCECKPRL IMEGLGLA