TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


8.B.6.2.1
Delta atracotoxin-Hv1a (Versutoxin) (42aas) (NMR structure available (1VTXA)). Antagonist of insect voltage-gated calcium channels (Chong et al., 2007; Khan et al., 2006; Wang et al., 1999) as well as sodium channels (Luch 2010).

Accession Number:P13494
Protein Name:Delta-hexatoxin-Hv1a
Length:42
Molecular Weight:4856.00
Species:hadronyche versuta (Blue mountains funnel-web spider) [6904]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF05353   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019871 F:sodium channel inhibitor activity
GO:0009405 P:pathogenesis

References (9)

[1] “Amino acid sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web spider Atrax versutus.”  Brown M.R.et.al.   3355530
[2] “Australian funnel-web spider toxin, versutoxin, enhances spontaneous synaptic activity in single brain neurons in vitro.”  Chieng B.et.al.   8281423
[3] “Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spider Hadronyche versuta.”  Nicholson G.M.et.al.   7816562
[4] “Selective alteration of sodium channel gating by Australian funnel-web spider toxins.”  Nicholson G.M.et.al.   9028001
[5] “Delta-atracotoxins from Australian funnel-web spiders compete with scorpion alpha-toxin binding on both rat brain and insect sodium channels.”  Little M.J.et.al.   9845331
[6] “Electrophysiological analysis of the neurotoxic action of a funnel-web spider toxin, delta-atracotoxin-HV1a, on insect voltage-gated Na+ channels.”  Grolleau F.et.al.   11171353
[7] “Variations in receptor site-3 on rat brain and insect sodium channels highlighted by binding of a funnel-web spider delta-atracotoxin.”  Gilles N.et.al.   11874465
[8] “Phase coupling of a circadian neuropeptide with rest/activity rhythms detected using a membrane-tethered spider toxin.”  Wu Y.et.al.   18986214
[9] “The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel.”  Fletcher J.I.et.al.   9384567
Structure:
1VTX     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	CAKKRNWCGK TEDCCCPMKC VYAWYNEQGS CQSTISALWK KC