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8.B.6.2.2
Delta hexatoxin-Mg1a; Neurotoxin Magi-4 (105aas).  Targets sites 3 and 4 of mammalian Na+ channels; slows inactivation (Yamaji et al., 2009).

Accession Number:P83560
Protein Name:Delta-hexatoxin-Mg1a
Length:105
Molecular Weight:12289.00
Species:macrothele gigas (Spider) [223896]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF05353   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019871 F:sodium channel inhibitor activity
GO:0009405 P:pathogenesis

References (2)

[1] “Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel.”  Corzo G.et.al.   12860384
[2] “Synthesis, solution structure, and phylum selectivity of a spider {delta}-toxin that slows inactivation of specific voltage-gated sodium channel subtypes.”  Yamaji N.et.al.   19592486
Structure:
2ROO     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTLVIACVA LVLVVVHGEV IEEVNEKQLQ ESVEEKYSLL QRLEKLDEAI TAEENRNSRV 
61:	RRCGSKRAWC KEKKDCCCGY NCVYAWYNQQ SSCERKWKYL FTGEC