8.B.8 The α-KTx15 Scorpion Toxin (α-KTx15) Family
Discrepin is a scorpion peptide that blocks preferentially the I(A) currents of the voltage-dependent K(+) channel of rat cerebellum granular cells. It was isolated from the venom of the buthid scorpion Tityus discrepans and contains 38 amino acid residues with a pyroglutamic acid at the N-terminal site. Discrepin has the lowest sequence identity (approx. 50%) among the six members of the α-KTx15 sub-family of scorpion toxins (Romeo et al., 2008).