TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.B.8.1.1









Discrepin (K+ channel toxin α-KTx15.6) (solution structure solved (2AXK_A); Prochnicka-Chalufour et al., 2006)
Eukaryota
Metazoa
Discrepin of Tityus discrepans (P84777)
*8.B.8.1.2









Tx3 toxin; active on A-type K+ and HERG currents (Huys et al., 2004)
Eukaryota
Metazoa
Tx3 of Buthus (Mesobuthus) martensii (Q8I0L5)
*8.B.8.1.3









Margatoxin MgTx; Toxin Ce; K+ channel toxin α-KTx of 39 aas.  Blocks Kv1.3/KCNA3 voltage-gated potassium channels of human T-lymphocytes but not Ca2+-activated K+ channel

Eukaryota
Metazoa
MgTx of Centruroides elegans (bark scorpion)
*8.B.8.1.4









K+ channel toxin 2.11 of 39 aas; also called Toxin Ce4.  

Eukaryota
Metazoa
Ce4 of Centruroides elegans
*8.B.8.1.5









Matentoxin-1 of 59 aas.

Eukaryota
Metazoa
Matentoxin-1 of Mesobuthus martensii
*8.B.8.1.6









Putative K+ channel inhibitor, αKTx30.3; SjKTx51

Eukaryota
Metazoa
KTx51 of Scorpiops jendeki
*8.B.8.1.7









Potassium channel toxin alpha-KTx 6.21; Urotoxin, of 62 aas. Blocker of voltage-gated potassium channels. It has highest activity on human voltage-gated potassium channel Kv1.2/KCNA2 channels, with an IC50 of 160 pM, whereas its affinity for other channels tested was in the nanomolar range (Luna-Ramírez et al. 2014).

Eukaryota
Metazoa
α-KTx 6.21 of Urodacus yaschenkoi (Inland robust scorpion)
*8.B.8.1.8









Potassium channel toxin alpha-KTx 6.11; male-specific potassium channel inhibitor IsTX of 63 aas and 1 N-terminal TMS.  Blocks voltage-gated potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3. Causes paralysis to crickets.

Eukaryota
Metazoa
ITx 6.11 of Opisthacanthus madagascariensis (Scorpion)