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8.B.8.1.1
Discrepin (K+ channel toxin α-KTx15.6) (solution structure solved (2AXK_A); Prochnicka-Chalufour et al., 2006)

Accession Number:P84777
Protein Name:Discrepin
Length:61
Molecular Weight:6787.00
Species:Tityus discrepans (Venezuelan scorpion) [57059]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF00451   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019870 F:potassium channel inhibitor activity
GO:0009405 P:pathogenesis

References (4)

[1] “Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans.”  D'Suze G.et.al.   19470401
[2] “Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cells.”  D'Suze G.et.al.   15369825
[3] “Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins.”  Batista C.V.F.et.al.   16705749
[4] “Solution structure of discrepin, a new K+-channel blocking peptide from the alpha-KTx15 subfamily.”  Prochnicka-Chalufour A.et.al.   16460026
Structure:
2AXK     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKAFYGMLVI FILCSTCYIS VDSQIDTNVK CSGSSKCVKI CIDRYNTRGA KCINGRCTCY 
61:	P