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8.B.8.1.2
Tx3 toxin; active on A-type K+ and HERG currents (Huys et al., 2004)

Accession Number:Q8I0L5
Protein Name:Tx3
Length:59
Molecular Weight:6206.00
Species:Mesobuthus martensii (Manchurian scorpion) (Buthus martensii) [34649]
Location1 / Topology2 / Orientation3: Secreted1
Substrate NONE

Cross database links:

Pfam: PF00451   

Gene Ontology

GO:0005576 C:extracellular region
GO:0019870 F:potassium channel inhibitor activity
GO:0009405 P:pathogenesis

References (4)

[1] “BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents.”  Huys I.et.al.   14599291
[2] “A new class of scorpion toxin binding sites related to an A-type K+ channel: pharmacological characterization and localization in rat brain.”  Vacher H.et.al.   11457451
[3] “Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus.”  Vacher H.et.al.   12473099
[4] “Functional consequences of deleting the two C-terminal residues of the scorpion toxin BmTX3.”  Vacher H.et.al.   12637022

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKFSSIILLT LLICSMSKFG NCQVETNVKC QGGSCASVCR KAIGVAAGKC INGRCVCYP