TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*8.B.9.1.1









Cycseine-rich venom protein, Triflin.  Blocks contraction of smooth muscle elicited by high potassium-induced depolarization.  May also target voltage-gated calcium channels (Cav) in smooth muscle cells.  The crystal structure of triflin, a snake venom derived blocker of high K+-induced artery contraction has been solved at 2.4A resolution. Triflin consists of two domains. The first 163 residues form a large globular body with an αβα sandwich core which resembles pathogenesis-related proteins of group-1 (PR-1). Two glutamic acid-associated histidine residues are located in an elongated cleft. A Cd2+ resides in this binding site, and forms a five-coordination sphere. The subsequent cysteine-rich domain adopts a rod-like shape, which is stabilized by five disulfide bridges. Hydrophobic residues, which may obstruct the target ion channel, are exposed to the solvent. A concave surface, which is surrounded by these two domains, may play a role in the binding to the target receptor, leading to ion channel blockage. The C-terminal cysteine-rich region has a similar tertiary structure to voltage-gated potassium channel blocker toxins such as BgK and ShK (Shikamoto et al. 2005).

Eukaryota
Metazoa
Triflin of Trimeresurus flavoviridis (Q8JI39)
*8.B.9.1.2









Natrin toxin, a snake venom cysteine-rich secretory protein that targets various ion channels (e.g., Ca2+ activated K+ channels, voltage-gated K+ channels, and ryanodine receptor Ca2+ channels). The 3-d structure is known (Zhou et al., 2008).
Eukaryota
Metazoa
Natrin of Naja atra (Q7T1K6)
*8.B.9.1.3









Helothermine of 242 aas.  Alters a variety of ion channel activities, including voltage-gated potassium channels (Kv), voltage-gated calcium channels (L-, N-, and P-type) (Cav) and ryanidine receptors (RyR) (Morrissette et al. 1995).

Eukaryota
Metazoa
Helothemine of Mexican beaded lizard (Heloderma horridum horridum)
*8.B.9.1.4









Cysteine-rich venom protein of 33 aas, Tripurin.

Eukaryota
Metazoa
Tripurin of Trimeresurus purpureomaculatus (shore pit viper)
*8.B.9.1.5









Basic Pathogenesis protein 1 of 177 aas, BPR1

Eukaryota
Viridiplantae
BPR1 of Nicotiana tabacum (common tobacco)
*8.B.9.1.6









Venom Allergen 5 of 254 aas

Eukaryota
Metazoa
Alleergen 5 of Culex quinquefasciatus (Southern house mosquito) (Culex pungens)