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9.A.16.1.1
Lysosomal-associated membrane glycoprotein-1 precursor, LAMP-1 (stabilizes TAPL (TC# 3.A.1.209.2) (Demirel et al., 2012).

Accession Number:P11279
Protein Name:Lysosome-associated membrane glycoprotein 1
Length:417
Molecular Weight:44882.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass type I membrane protein2
Substrate Unfolded proteins

Cross database links:

Genevestigator: P11279
eggNOG: NOG301998
HEGENOM: HOG000230942
Entrez Gene ID: 3916   
Pfam: PF01299   
KEGG: hsa:3916   

Gene Ontology

GO:0030425 C:dendrite
GO:0010008 C:endosome membrane
GO:0009897 C:external side of plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0042599 C:lamellar body
GO:0005770 C:late endosome
GO:0005765 C:lysosomal membrane
GO:0005764 C:lysosome
GO:0042470 C:melanosome
GO:0005624 C:membrane fraction
GO:0005771 C:multivesicular body
GO:0043025 C:neuronal cell body
GO:0042383 C:sarcolemma
GO:0048102 P:autophagic cell death
GO:0006914 P:autophagy

References (15)

[1] “Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences.”  Fukuda M.et.al.   3198605
[2] “The DNA sequence and analysis of human chromosome 13.”  Dunham A.et.al.   15057823
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Purification and characterization of human lysosomal membrane glycoproteins.”  Mane S.M.et.al.   2912382
[5] “Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000.”  Viitala J.et.al.   3131762
[6] “The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.”  Sawada R.et.al.   8517882
[7] “Structure of human lysosomal membrane glycoprotein 1. Assignment of disulfide bonds and visualization of its domain arrangement.”  Carlsson S.R.et.al.   2584229
[8] “The polylactosaminoglycans of human lysosomal membrane glycoproteins lamp-1 and lamp-2. Localization on the peptide backbones.”  Carlsson S.R.et.al.   2243102
[9] “Assignment of O-glycan attachment sites to the hinge-like regions of human lysosomal membrane glycoproteins lamp-1 and lamp-2.”  Carlsson S.R.et.al.   8323299
[10] “Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.”  Zhang H.et.al.   12754519
[11] “Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.”  Liu T.et.al.   16335952
[12] “The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.”  Johansson M.et.al.   16176980
[13] “Integral and associated lysosomal membrane proteins.”  Schroeder B.et.al.   17897319
[14] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[15] “Initial characterization of the human central proteome.”  Burkard T.R.et.al.   21269460

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAPGSARRP LLLLLLLLLL GLMHCASAAM FMVKNGNGTA CIMANFSAAF SVNYDTKSGP 
61:	KNMTFDLPSD ATVVLNRSSC GKENTSDPSL VIAFGRGHTL TLNFTRNATR YSVQLMSFVY 
121:	NLSDTHLFPN ASSKEIKTVE SITDIRADID KKYRCVSGTQ VHMNNVTVTL HDATIQAYLS 
181:	NSSFSRGETR CEQDRPSPTT APPAPPSPSP SPVPKSPSVD KYNVSGTNGT CLLASMGLQL 
241:	NLTYERKDNT TVTRLLNINP NKTSASGSCG AHLVTLELHS EGTTVLLFQF GMNASSSRFF 
301:	LQGIQLNTIL PDARDPAFKA ANGSLRALQA TVGNSYKCNA EEHVRVTKAF SVNIFKVWVQ 
361:	AFKVEGGQFG SVEECLLDEN SMLIPIAVGG ALAGLVLIVL IAYLVGRKRS HAGYQTI