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9.A.26.1.2
The suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative flippase that exports LCBs across the cytoplasmic membrane, Rsb1p

Accession Number:Q08417
Protein Name:Rsb1p
Length:382
Molecular Weight:43187.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Long-chain bases

Cross database links:

Genevestigator: Q08417
eggNOG: fuNOG05435
HEGENOM: HBG202818
DIP: DIP-3834N
RefSeq: NP_014692.1   
Entrez Gene ID: 854214   
Pfam: PF04479   
KEGG: sce:YOR049C   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0004012 F:phospholipid-translocating ATPase activity
GO:0015908 P:fatty acid transport
GO:0045332 P:phospholipid translocation
GO:0006950 P:response to stress

References (5)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.”  Dujon B.et.al.   9169874
[2] “Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release.”  Kihara A.et.al.   12034738
[3] “Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry.”  Kihara A.et.al.   15342785
[4] “Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria.”  Panwar S.L.et.al.   16407254
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSNATNNTLG SLLPQLEAAA NSNSLYGGMV PNLRFNITMI VIWGILLTIH VVQLLMRQYW 
61:	FSIAFICTGI LEVLGFIGRT WSHSNVADMD AFLLNMICLT IAPVFTMGGI YYQLAKLIEV 
121:	YGHRFSLLPS PMAYSFIFIC SDIVSLVVQA VGGGLCGVAV TDGTSTTTGN HVFIAGLAIQ 
181:	VASMAIFLML WFHFLFRIYI SVRWEHINSR PISLSLLKIS QTEVDYLYRE KFHFLRLEPK 
241:	RWVFHYFNLA ITVAVLTIFT RCCYRLAELV VGWDGYLITH EWYFIILDAL MMAIATVTLT 
301:	IFHPGFAFKG RSTSIPITPG HVDPETLPHT DDVEDILDTS DSKQFDIEKE EFQASMKYPI 
361:	STFKQFMSKI ANLFSSKKKA KL