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9.A.26.1.3
Plasma membrane inducible protoporphyrin uptake porter, Pug1 (may also catalyze heme efflux (Protchenko et al., 2008)).

Accession Number:P40100
Protein Name:Pug1
Length:303
Molecular Weight:33733.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Protoporphyrin, Heme

Cross database links:

Genevestigator: P40100
eggNOG: fuNOG10056
HEGENOM: HBG447992
RefSeq: NP_011112.1   
Entrez Gene ID: 856934   
Pfam: PF04479   
KEGG: sce:YER185W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015886 P:heme transport
GO:0006950 P:response to stress

References (4)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[2] “Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions.”  Kim H.et.al.   12524434
[3] “Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae.”  Protchenko O.et.al.   18326586
[4] “Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes.”  Kung L.A.et.al.   19756047

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTTDSGFVL YHYTPSKAAA IVFVVLFIIM TVIFAVQTLY AARKSSKALK NNPFESSDDK 
61:	VDSLEDAEYK QLKITPTVFA FIPFFTGCIM EAVGYIGRAL SSSNPERTTP YIIQSVLLLV 
121:	APALIAATIY MIFGRLLHVM RCQSLILISA RFGTTFFVVG DVFSFFLQAA GGGLMSKAGS 
181:	TKTGSGLITA GLFVQVIFFG FFIINEIRFT VNVKRRCLFY EDISRKWIFV NATLLLSSML 
241:	ILLRSIVRIV EFIQGFNGYI ISHEYFIYVF DAVPMLLVII AFSVGSFFGN VFDVIKECQT 
301:	LSN