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9.A.33 The Pyocin R2 Phage P2 Tail Fiber Protein (Pyocin R2) Family

Pseudomonas aeruginosa produces R-type pyocins that resemble tail fibers of phage P2. These pyocins resemble contractile but non-flexible tail fiber proteins of phage P2. In fact, pyocin R2 is homologous to P2 phage tail fiber proteins and is derived from an ancestral protein sharing a common origin with it. Pyocin R2 (PRF15) is large (701 aas) and has several (~5) regions that may be sufficiently hydrophobic to pass through the membrane as α-helices (Nakayama et al. 2000).

R-type pyocins cause depolarization of the cytoplasmic membrane of sensitive cells, and they inhibit active transport. These observations are consistent with, but do not prove pore formation.

References associated with 9.A.33 family:

Nakayama, K., K. Takashima, H. Ishihara, T. Shinomiya, M. Kageyama, S. Kanaya, M. Ohnishi, T. Murata, H. Mori, and T. Hayashi. (2000). The R-type pyocin of Pseudomonas aeruginosa is related to P2 phage, and the F-type is related to lambda phage. Mol. Microbiol. 38: 213-231. 11069649