TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*9.A.35.1.1









Syndecan-4 of 198 aas.  Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. The syndecan-syntenin-ALIX complex plays a role  in membrane transport and signalling processes (Baietti et al. 2012).

Eukaryota
Metazoa
Syndecan-4 of Homo sapiens (P31431)
*9.A.35.1.2









Syndecan-1 of 310 aas and 2 TMSs, N- and C-terminal.  The binding of cytokines and growth factors to heparan sulfate (HS) chains on proteoglycans generates gradients that control development and regulate wound healing. Syndecan-1 (sdc1) is an integral membrane HS proteoglycan. Its structure allows it to bind with cytosolic, transmembrane, and extracellular matrix (ECM) proteins. It plays important roles in mediating key events during wound healing because it regulates a number of important processes, including cell adhesion, cell migration, endocytosis, exosome formation, and fibrosis (Stepp et al. 2015).

Eukaryota
Metazoa
Syndecan-1 of Homo sapiens